Bacterial Detection and Antibacterial Applications Based on Nanozymes

Disease caused by bacterial infections is one of the major problems affecting human health worldwide. Therefore, there is an urgent need to develop new, efficient, bacteria-binding antimicrobial agents. Due to its unique advantages, nanozymes have attracted increasing attention from researchers. In contrast to native enzymes, nanozymes can destroy many Gram-positive and Gram-negative bacteria, creating an important bridge between biology and nanotechnology. There has been an increasing amount of research around antimicrobial applications with nanozymes, such as bacterial detection, killing drug-resistant bacteria, treating bacterial infection-related diseases, and environmental pollution prevention.

Nanozymes are inorganic nanostructures with intrinsic enzyme activity for bacterial detection and various antimicrobial applications. Creative Enzymes, as a leading global company, is committed to helping our clients achieve effective and successful research. We provide novel enzymes for bacterial detection and antimicrobial applications. In addition, we deliver reliable results and reports on time to our customers around the world.

Fig. 1 The use of nanozymes in antibacterial applications.

Detection of Bacteria with Nanozymes

• Rapid and sensitive bacterial detection is of great significance for the rapid diagnosis of bacterial diseases, food safety monitoring and public health assurance.
• At present, many kinds of nanozymes have been used in bacterial detection technology.
• Creative Enzymes establishes many bacterial detection methods based on nanozyme with high sensitivity, including Escherichia coli, Listeria monocytogenes, Salmonella and so on.

Eliminating Drug-Resistant Bacteria with Nanozymes

• At present, the abuse of antibiotics caused by Bacteria Resistant (Antibiotic Resistant Bacteria) serious threats to global public health and life.
• Traditional antibiotics are partly derived from natural products and partly chemically synthesized. Compared with conventional antibiotics, nanozymes are less likely to induce bacterial resistance.
• The pathways of nanozymes against drug-resistant bacteria include catalyzing the generation of reactive oxygen species (ROS), releasing metal ions, enhancing bacterial autophagy, and combination therapy to kill bacteria. Based on this research, Creative Enzymes has designed various nanozymes to kill resistant bacteria.

Clearing Biofilms with Nanozyme

• Biofilm refers to a structured community formed by microorganisms such as bacteria and fungi adsorbed on solid surfaces. A biofilm matrix is composed primarily of extracellular polymeric substances such as polysaccharides, proteins, nucleoids and lipids to embed bacteria or fungi inside.
• One of the challenges of traditional approaches to biofilm-related diseases is that it is difficult for drugs to kill bacteria encapsulated in biofilms by extracellular matrix, resulting in higher resistance of bacteria in biofilm form.
• Creative Enzymes develops novel methods based on nanozyme has played a good role in removing biofilm.

Treatment of Bacterial Infectious Diseases with Nanozymes

• With the rapidly approaching post-antibiotic era, new and effective combinations of antibiotics are imperative to combat multiple drug resistance. Nanozymes are particularly promising for the treatment of bacterial infectious diseases, characterized by sustained therapeutic efficacy, low immunogenicity, stability, and manageable toxicity.
• Creative Enzymes provides types of nanozymes for treatment of bacterial infectious diseases, including wound disinfection, bacterial keratitis, oral ulcer, enteritis, pulmonary infection and so on.

Preventing Biofouling with Nanozymes

• Biological contamination is a serious contamination phenomenon caused by non-specific surface adhesion of microorganisms, which can lead to corrosion of metal surfaces and contamination of medical equipment.
• Creative Enzymes develops nanozymes that have the function of preventing biological contamination.

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