Anti-Tumor Formation with Nanozymes

Cancer is a serious threat to human life and health and is also one of the main causes of human death. Today, radiotherapy, chemotherapy and surgical resection are still the main cancer treatment strategies, but these treatments still have strong side effects. Radiation and chemotherapy are easy to damage normal tissues and organs, causing damage to human health. In addition, surgical resection is difficult to remove residual tumor cells in the blood and lymphatic system. Therefore, it is very important to find new safe and efficient tumor treatment strategies.

Enzyme therapy can catalyze the reaction in vivo to achieve tumor treatment, and it can also activate human immune capacity and improve the function of the immune system. The use of enzyme therapy for tumor treatment has attracted the attention of researchers. Creative Enzymes provides nanozymes in the field of anti-tumor formation for research purposes to customers worldwide.

Relieving Hypoxia in Tumors with Nanozymes

• The tumor microenvironment (TME) is characterized by hypoxia and acidity, which are not suitable for the survival of normal cells, but this abnormal environment unexpectedly enhances the mutation of tumor cells, and then aggravates the proliferation of tumor cells.
• Nanozymes can produce ROS through OXD and POD activities to induce oxidative stress and kill tumor cells. They can also catalyze the decomposition of H₂O₂ to produce O₂ in the tumor microenvironment through CAT activity to alleviate tumor tissue hypoxia and indirectly induce tumor cell death.
• Based on these principles, Creative Enzymes provides varieties of nanozymes to relieve hypoxia in tumors, including Pt, CeO₂, BiO_2-x, MnO₂ and others.

ROS-Producing Tumor Catalytic Therapy with Nanozymes

• ROS and oxidation are also involved in cancer progression. Therefore, ROS scavenging nanozymes have been studied in the field of cancer therapy.
• Creative Enzymes provides Au / HCN, Ni / hemin, TiN, Pd / Cu / Fe, MnO_x nanozymes for ROS-producing tumor catalytic therapy.

Tumor Immunotherapy with Nanozymes

• Tumor metastasis and recurrence is still the most serious challenge in cancer treatment. Catalytic immune regulation can activate the body's own immune system, which is an effective way to inhibit tumor metastasis and recurrence.
• The tumor microenvironment is in an immune-suppressive state. Under hypoxia, tumor-associated macrophages express immunosuppressive M2-type macrophages, while the M2-type cells that kill tumor cells are less expressed. Therefore, improving the tumor immunosuppressive microenvironment by nano-enzymes and realizing the synergy between nano-enzyme tumor catalytic therapy and immunotherapy will greatly improve the efficiency of tumor treatment.

Fig. 1 Cu_2−xTe nanozyme for catalytic immunotherapy. (a) Proposed cascade reactions catalyzed by Cu_2-xTe nanozyme. (b) Scheme of the nanozyme-induced immunogenic cell death under the excitation of NIR-II.

• Inspired by these discoveries, Creative Enzymes offers Cu_2-xTe, IMSN-PEG-TI, GHZD, PHCN nanozymes and others for tumor immunotherapy.

Creative Enzymes has extensive experience and expertise in nanozyme services. We are committed to providing you with timely and high-quality deliverables. At the same time, we guarantee the cost-effectiveness, completeness and simplicity of the report. If you are interested in our services or have any questions, please feel free to contact us or make an online inquiry.