Human Kininogen (Single Chain High Molecular Weight)

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Cat No.

CZY-028

Description

High Molecular Weight Kininogen (HK) is a non-enzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links Prekallikrein to a negatively charged surface thereby allowing activation of Kallikrein by surface bound Factor a-XIIa. HK also forms a complex with Factor XI and accelerates its activation to XIa by a-XIIa. Additionally HK serves as a source of Bradykinin, a potent vasoactive peptide important in hypotension studies. The protein purity is determined by SDS-PAGE.

Source

Human

Package

1mg

Molecular Weight

120000

Purity

>95% by SDS-PAGE

Concentration

1.91 mg/mL (before lyophilization)

Storage

2-8°C

Buffer

4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3

Localization

Plasma

Extinction coefficient

7.01

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Project Description:

For research and industrial use only, not for personal medicinal use.

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