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Enzyme for Antibody Research

Nowadays, antibodies have become the most popular studied category for their functions in diseases and drugs. Although the research has been improved step by step from chimeric antibodies to human antibodies, there are still many challenges in the area, such as structure characterization and conjugation. Focused on analysis and modification of peptides and glycans, Creative Enzymes offers high quality enzyme products to support the most advanced research on antibodies.

  • Full range of products cover IgG proteases and IgG glycosidase
  • Highly site- and sequence-specific
  • Innovative and unique enzymes
  • Short incubation time, 30 min to 2 h

Proteases

  • The main function of IgG proteases is to digest IgG to generate Fab and Fc fragements for subsequence analysis or modification purposes.
IgG Proteases
Cat. No. Target Features Inquiry
NATE-1598 IgG
  • One specific cleavage site below the hinge region. No risk of over digestion.
  • Digestion under physiological conditions, preserving immunoreactivity.
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NATE-1599 Mouse IgG2a, IgG3
NATE-1600 All subclasses IgG (human, mouse, rat, goat and sheep)
NATE-1601 Human IgG1

We also have immobilized enzymes for IgG and IgM fragmentation.

IgG/IgM Proteases
Cat. No. Target Features Inquiry
NATE-1864 IgG
  • Mild digestion conditions, high efficiency.
  • Immobilized for ease of separation from cleavage products.
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NATE-1865 Mouse IgG1
NATE-1866 IgG / IgM
NATE-1867 IgM

Glycosidases

  • The main function of IgG glycosidases is to hydrolyze glycans from the Fc region.
IgG Glycosidases
Cat. No. Target Features Inquiry
NATE-1603 Complex N-linked glycans in the native IgG Fc region
  • Reduce the complexity of antibody
  • Modify glycosylation
  • Rapid and mild reactions
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NATE-1604 All glycoforms on IgG, including high-mannose
NATE-0603* High mannose, hybrid, and complex N-glycans

*Other sources of PNGase F are also available.

Characterization

  • Arginine specific protease digests proteins C-terminal to arginine residues and is used for antibody characterization.
Characterization Proteases
Cat. No. Target Applications Inquiry
NATE-1602 Arg-X motifs in peptides and proteins
  • Peptide mapping
  • Protein sequence analysis
  • Protein fingerprinting
  • Post-translational modification analysis
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Antibody Labeling and Conjugation

  • Creative Enzymes's unique technology for covalent conjugation of a label to the Fc domain of the antibody. Besides, enzymes were developed and optmized as labels for antibody labelling.
Enzymes Labels
Cat. No. Product Name Inquiry
NATE-0550 Native Horseradish Peroxidase Get a quote
NATE-0054 Native Calf Alkaline Phosphatase Get a quote
NATE-0311 Native Aspergillus niger Glucose Oxidase Get a quote
DIA-189 Native Escherichia coli β-Galactosidase Get a quote
Antibody Conjugation
Service Target Conjugation Inquiry
Label service IgG
  • Alexa Fluor® 488
  • Biotin
  • Deferoxamine (DFO)
  • Azide Activation
  • Enzyme label
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Creative Enzymes is engaged in providing advanced and powerful enzyme tools for antibody-based bio-therapeutic research. Please feel free to contact us for professional technical support.