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α-Amyloid Precursor Protein Modulator


Cat No.
COEC-109
Description
α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. α-Amyloid Precursor Protein Modulator displays a marked loss of tumor promoting activity.
Applications
A cell-permeable benzolactam derived PKC activator
Form
Solid
CAS No.
497259-23-1
Molecular Weight
501.55
Purity
≥95%
Synonyms
(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam; PKC Activator V
Molecular Formula
C27H30F3N3O3
Solubility
Soluble in DMSO (50 mg/ml), and methanol (1 mg/ml).
Boiling Point
~728.8° C at 760 mmHg (Predicted)
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