(-)-Huperzine A

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Cat No.

CEI-0211

Description

(-)-Huperzine A

CAS_No

102518-79-6

Molecular Weight

242.32

Purity

>99%

Storage

2 years -20centigrade Powder

Targets

Acetylcholinesterase

Molecular Formula

C15H18N2O

Chemical Name

4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Solubility

DMSO0.66 mg/mL, Water

In vitro

(-)-Huperzine A is a novel alkaloid isolated from the Chinese herb Huperzia serrata. (-)-Huperzine A preferentially inhibits tetrameric AChE (G4 form). (-)-Huperzine A is more potent than tacrine, physostigmine, galanthamine, and rivastigmine with respect to inhibition of AChE activity, whereas HupA is the least potent BuChE inhibitor among the inhibitors. (-)-Huperzine A possesses the ability to protect cells against hydrogen peroxide, beta-amyloid protein, glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53, and caspase-3, protect mitochondria, upregulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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