β-Lapachone

inquiry

Cat No.

CEI-0468

Description

Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin, β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC50 =3.6 µM).

Appearance

White solid

Product Overview

A DNA topoisomerase I inhibitor and a histone demethylase (HDM) inhibitor

CAS_No

4707-32-8

Molecular Weight

435.52

Purity

>98% by TLC

Storage

-20 centigrade

Targets

TOP1MT

Molecular Formula

C15H14O3

Chemical Name

3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione

Solubility

DMSO (~ 25 mg/ml)

Shipping Conditions

Gel pack

Name:

Email *

Phone:*

Company/Institution:

Country or Region:

Quantity:

Services & Products Interested *

Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

Products

Online Inquiry