α-Methyl-L-leucine

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Cat No.

CEGZ-6940

Description

α-Methyl-L-leucine is an α-methylated analogue of the proteinogenic amino acid L-leucine in which the α-hydrogen is replaced by a methyl group, creating a quaternary α-carbon that strongly restricts backbone conformational freedom.

Applications

Used as a building block in peptide synthesis and medicinal chemistry for the preparation of conformationally constrained, protease-resistant peptide analogues.

Product Overview

α-Methyl amino acids are valuable tools in peptide and medicinal chemistry: their incorporation stabilizes helical conformations, confers marked resistance to proteolytic degradation, and can improve the pharmacological profile of peptide-based compounds.

CAS_No

105743-53-1

Molecular Weight

145.20

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

2-methyl-L-leucine; L-2-amino-2,4-dimethylpentanoic acid

Molecular Formula

C7H15NO2

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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