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4-Methylumbelliferone sodium salt

Cat No.
CSUB-0670
Description
4-Methylumbelliferone sodium salt is a selective inhibitor of Hyaluronan (HA) synthesis. HA is a major component in the metastasis of malignant tumors. Studies indicate that in the presence of 4-Methylumbelliferone sodium salt cell proliferation, migration, and growth are inhibited, while apoptosis is induced. In addition, the motility and cell growth was inhibited in fibroblast cell line NIH/3T3 (sc-2210). 4-Methylumbelliferone sodium salt is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis. It is also believed that 4-Methylumbelliferone sodium salt can suppress the expression of HA-synthase.
Applications
β-Galactosidase activity in solution can be revealed by the fluorogenic substrate 4-methylumbelliferone. It is also a selective inhibitor of Hyaluronan (HA) synthesis and
Form
Solid
CAS No.
5980-33-6
Molecular Weight
198.15
Purity
>98%
Storage
Store at room temperature
Synonyms
Cantabiline sodium; 7-Hydroxy-4-methylcoumarin
Molecular Formula
C10H7O3•Na
Solubility
Soluble in water
Substrates
Mannosidase
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