4-Methylumbelliferone

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Cat No.

CEI-0375

Alias

4-MU

CAS_No

90-33-5

Molecular Weight

176.17

Purity

>99%

Storage

2 years at -20 centigrade

Synonyms

4-MU

Targets

HA synthesis

Molecular Formula

C10H8O3

Chemical Name

1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Solubility

DMSO 35 mg/mL, Water

In vitro

4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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