4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid

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Cat No.

NATZ-099

Description

4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.

Form

A crystalline solid

CAS_No

66966-09-4

Molecular Weight

352.3

Purity

90%

Storage

-20°C

Synonyms

4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid
4-MU-α-IdoA
MU-α-IdoA

Molecular Formula

C16H16O9

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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