Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

A-966492

Cat No.
CEI-0324
Description
As a novel inhibitor, A-966492 can potently inhibit PARP1 and PARP2 with Ki of 1 nM and 1.5 nM,
CAS No.
934162-61-5
Molecular Weight
324.35
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PARP1
Molecular Formula
C18H17FN4O
Chemical Name
2-(2-fluoro-4-((S)-pyrrolidin-2-yl)phenyl)-3H-benzo[d]imidazole-4-carboxamide
Solubility
DSMO 65 mg/mL Water
In vitro
A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Kiof 1 nM.
In vivo
A-966492 shows good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin. In vivo, A-966492 demonstrates significant enhancement of the efficacy of TMZ in a murine B16F10 syngeneic melanoma model, with the A-966492 combination groups showing superior efficacy.
0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product