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Enzymes for Research, Diagnostic and Industrial Use

AG-1024 (Tyrphostin)

Cat No.
CEI-0035
Description
AG-1024 (Tyrphostin)
CAS No.
65678-07-1
Molecular Weight
305.17
Purity
>99%
Storage
2 years at -20 centigrade
Targets
IGF-1R
Molecular Formula
C14H13BrN2O
Solubility
No
In vitro
Tyrphostin AG1024 can inhibit IGF-1R with IC50 of around 400 nM. By inhibiting insulin-like growth factor 1 receptor and insulin receptor, Tyrphostin AG1024 arrested melanoma cell growth. Tyrphostin AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function.
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