Products

Enzymes for Research, Diagnostic and Industrial Use

CL075

Cat No.
LIGC-007
Description
CL075 is a thiazoloquinolone derivative that stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12. CL075 seems also to induce the secretion of IFN-α through TLR7 but to a lesser extend. It induces the activation of NF-κB at 0.4 µM (0.1 µg/ml) in TLR8-transfected HEK293 cells, and ~ 10 times more CL075 is required to activate NF-κB in TLR7-transfected HEK293 cells.
Appearance
Yellow lyophilized powder
Molecular Weight
243.33
Concentration
Working Concentration:
0.1 - 5 μg/ml CL075 for human TLR8 and mouse TLR7
0.5 - 5 μg/ml CL075 for human TLR7
Specificity
human TLR7/8 and mouse TLR7 agonist
Stability
Lyophilized product is stable 1 year at -20°C when properly stored. Resuspended CL075 should be aliquoted and stored at -20°C. Resuspended product is stable 6 months at -20°C. Avoid repeated freeze-thaw cycles.
Storage
Store at -20°C.
Molecular Formula
C13H13N3S
Solubility
1 mg/ml in water
Endotoxin Level
<0.001 EU/µg
Download Datasheet:



Inquiry
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: