Products

Enzymes for Research, Diagnostic and Industrial Use

CL075


Cat No.
LIGC-007
Description
CL075 is a thiazoloquinolone derivative that stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12. CL075 seems also to induce the secretion of IFN-α through TLR7 but to a lesser extend. It induces the activation of NF-κB at 0.4 µM (0.1 µg/ml) in TLR8-transfected HEK293 cells, and ~ 10 times more CL075 is required to activate NF-κB in TLR7-transfected HEK293 cells.
Appearance
Yellow lyophilized powder
Molecular Weight
243.33
Concentration
Working Concentration:
0.1 - 5 μg/ml CL075 for human TLR8 and mouse TLR7
0.5 - 5 μg/ml CL075 for human TLR7
Specificity
human TLR7/8 and mouse TLR7 agonist
Stability
Lyophilized product is stable 1 year at -20°C when properly stored. Resuspended CL075 should be aliquoted and stored at -20°C. Resuspended product is stable 6 months at -20°C. Avoid repeated freeze-thaw cycles.
Storage
Store at -20°C.
Molecular Formula
C13H13N3S
Solubility
1 mg/ml in water
Endotoxin Level
<0.001 EU/µg
Download Datasheet:



Inquiry
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country or Region:
Company/Institution:
*Products or Services of Interest:
Quantity:
Project Description:
Our products are not intended for direct clinical use!
*Verification Code:
Verification code

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.


Sitemap | Privacy Policy | Terms and Conditions
Copyright ©2011 - 2021 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-516-512-3133
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country or region:
     
0
Click unfold / close
Inquiry Basket
Delete selected Check Out
Decide to move out of the shopping cart??

Sure No, Back
 

Please choose product!

< Go Back
You have already added to buy this product