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Caspase-7 from Human, Recombinant

Cat No.
NATE-0815
Description
Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
Abbr
CASP7, Recombinant (Human)
Alias
CASP7
Source
E. coli
Species
Human
Applications
Used to screen caspase inhibitors, study enzyme regulation, determine caspase substrate specificity, or as positive control in caspase activity assays.
Appearance
Lyophilized
Enzyme Commission Number
EC 3.4.22.-
Activity
~25,000U/mg protein
Purity
90% (SDS-PAGE)
Storage
-80°C
Preparation Instructions
After reconstitution, prepare aliquots and store at -80°C
Synonyms
CASP7; CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3; Caspase-7
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