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Matrix Metalloproteinase-8 from Human, Recombinant


Cat No.
NATE-0862
Description
Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes.
Abbr
MMP-8, Recombinant (Human)
Alias
MMP-8; PMNL-CL; HNC; CLG1
Source
E. coli
Species
Human
Applications
Used as a standard for analyzing mammalian collagenase activity.
Appearance
Sterile Filtered clear solution.
Product Overview
Matrix Metalloproteinase-8 Human Recombinant produced in E. coli is a single, nonglycosylated, polypeptide chain having a molecular mass of 75 kDa. The MMP-8 is purified by proprietary chromatographic techniques.
Enzyme Commission Number
EC 3.4.24.34
Activity
100 units/ml
CAS No.
2593923
Molecular Weight
75 kDa
Purity
Greater than 90% as determined by SDS-PAGE.
Unit Definition
One unit of collagenolytic activity is defined as the cleavage of 1µg of collagen per minute by the solution method.
Stability
MMP-8 although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Buffer
The protein Solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, containing 0.2M NaCl, 5mM CaCl2, 0.0025% NaN3 and 0.1% BSA.
Synonyms
Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1
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