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Native Bacillus sp. Purine Nucleoside Phosphorylase

Cat No.
DIA-164
Description
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in either enzyme result in a severe combined immunodeficiency (SCID). Confusingly, the same abbreviation (PNPase), is also used for another, otherwise unrelated, enzyme, namely Polynucleotide Phosphorylase.
Abbr
PNPase (Bacillus sp.)
Alias
PNPase; PUNPI; PUNPII
Source
Bacillus sp.
Applications
Useful for enzymatic determination of inorganic phosphate
Appearance
Colourless to light brown solution
Product Overview
Purine Nucleoside Phosphorylase produced in microorganism has a molecular mass of 32 kDa.
Form
Liquid
Enzyme Commission Number
EC 2.4.2.1
Activity
> 500U/mL
CAS No.
9030-21-1
Contaminants
NADH oxidase < 0.002%
pH Stability
6.0-10.0 (37°C (Tris-HCI buffer)
Optimum pH
8
Thermal stability
Stable at 65°C and below (pH 8.5, 10 mins)
Storage
-20°C
Inhibitors
Ag+, Hg2+
Pathway
Nicotinate and nicotinamide metabolism; Purine metabolism; Pyrimidine metabolism; Nucleotide metabolism.
Function
purine-nucleoside phosphorylase activity; purine-nucleoside phosphorylase activity; purine-nucleoside phosphorylase activity.
Synonyms
inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; purine-nucleoside: phosphate ribosyltransferase; EC 2.4.2.1
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Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogDIA-216
EC No.EC 2.4.2.1
CAS No.9030-21-1
SourceMicroorganism
CatalogNATE-0606
EC No.EC 2.4.2.1
CAS No.9030-21-1
SourceMicroorganisms
CatalogNATE-0607
EC No.EC 2.4.2.1
CAS No.9030-21-1
SourceE. coli
CatalogNATE-0644
EC No.EC 2.4.2.1
CAS No.9030-21-1
SourceE. coli
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