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Native Bovine α-Chymotrypsin
Cat No.
NATE-0746
Description
Chymotrypsin is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. It is activated in the presence of trypsin.
Abbr
α-Chymotrypsin, Native (Bovine)
Alias
avazyme; chymar
Source
Bovine Pancreas
Species
Bovine
Applications
Chymotrypsin (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. It is activated in the presence of trypsin. The hydrophobic and shape complementarity between the peptide substrate P1 sidechain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine and methionine at the P1 position. Structurally, it is the archetypal structure for its superfamily, the PA clan of proteases.
Form
lyophilized powder
Enzyme Commission Number
EC 3.4.21.1
Activity
> 40 units/mg protein
CAS No.
9004-07-3
Storage
−20°C
Function
serine-type endopeptidase activity
Synonyms
EC 3.4.21.1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin
Download
Download Datasheet"Chymotrypsin" Total Products Page
| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1890 | Chymotrypsin from Human, Recombinant | EC 3.4.21.1 | 9004-07-3 | E. coli | Inquiry |
| NATE-1894 | Sequencing Grade Chymotrypsin from Human, Recombinant | EC 3.4.21.1 | 9004-07-3 | E. coli | Inquiry |
| DIGS-227 | Chymotrypsin | EC 3.4.21.1 | 9004-07-3 | Inquiry | |
| NATE-0747 | Native Human α-Chymotrypsin | EC 3.4.21.1 | 9004-07-3 | Human pancreas | Inquiry |