Description
Pyruvate kinase M2 (PKM2) is an isoform of pyruvate kinase that is expressed in certain differentiated cells and in proliferatively active cells. PKM2 is often overexpressed in cancer cells.
Abbr
PKM2, Recombinant (Mouse)
Form
Aqueous solution, Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.
Purity
Greater than 90% (SDS-PAGE)
Unit Definition
One unit is defined as the amount of enzyme required to transfer a phosphoryl group from phosphoenolpyruvate (PEP) to 1 pmol of ADP/min at 37°C.
Storage
Store at -70°C. Avoid multiple freeze-thaw cycles.
Synonyms
M2-PK tumor; OPA-interacting protein 3 (OIP-3); Pyruvate kinase 3 (PK3); Pyruvate kinase; muscle; Thyroid hormone-binding protein 1 (THBP1); Pyruvate kinase; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase
