A66

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Cat No.

CEI-0127

Description

A66 can inhibit p110-alpha with IC50 of 32 nM.

CAS_No

1166227-08-2

Molecular Weight

393.53

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

p110-alpha

Molecular Formula

C17H23N5O2S2

Chemical Name

(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide

Solubility

DMSO 79 mg/mL Water

In vitro

A66 is a high selective PI3K inhibitor which can inhibit PI3K-alpha with 32 nM. A66 inhibits p110-alpha E545K and p110-alpha H1047R with IC50 of 30 nM and 43 nM. A66 shows strong inhibition to p110-alpha and little inhibition to other PI3K isoform. A66 can inhibit cell lines harboring H1047R mutations in PIK3CA and have high levels of p110-alpha and class-Ia PI3K activity.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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