A83-01

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Cat No.

CEI-0952

Description

Potent and selective ALK4, 5 and 7 inhibitor. IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency. Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts. Active in rat models. Cell permeable

Abbr

A83-01(ALK)

Alias

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Appearance

Light Yellow powder

Product Overview

ALK inhibitor

CAS_No

909910-43-6

Molecular Weight

421.5

Purity

>98% (TLC); NMR (Conforms)

Synonyms

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Targets

ALK

Molecular Formula

C25H19N5S

Solubility

May be dissolved in DMSO (20mg/ml)

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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