ABT-888

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Cat No.

CEI-0636

Description

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.

Appearance

Orange solid

Product Overview

A PRP-1 and PARP-2 inhibitor

CAS_No

912445-05-7

Molecular Weight

242.27

Purity

>98% by TLC

Storage

-20 centigrade

Targets

Protein Synthesis

Molecular Formula

C₁₃H₁₆N₄O.2HCl

Chemical Name

2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride

Solubility

DMSO (100 mM) or EtOH (50 mM)

Shipping Conditions

Gel pack

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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