AC220 (Quizartinib)

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Cat No.

CEI-0055

Description

AC220 can inhibit FLT-3 ITD and FLT-3 wild type with IC50 of around 1.1 nM and 4.2 nM.

CAS_No

950769-58-1

Molecular Weight

560.67

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

Flt3(ITD), Flt3(WT)

Molecular Formula

C29H32N6O4S

Chemical Name

Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-

Solubility

DMSO 33.2 mg/mL Water

In vitro

AC220 can inhibit FLT-3 ITD and FLT-3 wild type with IC50 of around 1.1 nM and 4.2 nM. AC220 inhibits cell proliferation of MV4-11 cell line with IC50 of 0.56 nM.

In vivo

Treatment with AC220 at 10 mg/kg in the MV4-11 tumor xenograft model is better than that of sunitinib.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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