Ac-VDVAD-AFC

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Cat No.

CSUB-0744

Description

Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2. It is similar to Ac-VDVAD-AMC but the AFC fluorophore has a greater Stokes' shift upon cleavage. VDVAD has been found to be a preferred cleavage site for caspase-2 (Ich-1L). Increases in Ac-VDVAD-AFC cleavage is correlated with losses in procaspase-2 (conversion to active caspase-2) in human neuroblastoma lines induced to apoptosis with C2-ceramide and NO.

Applications

A fluorogenic substrate for caspase-2

Form

Solid

CAS_No

210344-94-8

Molecular Weight

770.71

Storage

Store at -20° C

Synonyms

Caspase Substrate (AFC); Ac-Val-Asp-Val-Ala-Asp-AFC

Molecular Formula

C33H41F3N6O12

MDL Number

MFCD04037014

Solubility

Soluble in DMSO (20 mM), and DMF (20 mM).

Substrates

Caspase-6; Cysteine proteases

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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