ADAM 17 endopeptidase

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Cat No.

EXWM-4370

Description

In peptidase family M12. In vivo, the cleavage of tumour necrosis factor α precursor releases the soluble, 17-kDa TNFα, which induces inflammation.

Form

Liquid or lyophilized powder

Enzyme Commission Number

EC 3.4.24.86

CAS_No

151769-16-3

Storage

Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.

Synonyms

tumor necrosis factor α-converting enzyme; TACE

Reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala┼Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor α (TNFα). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains

Notes

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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