AG-879

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Cat No.

CEI-0956

Description

Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells. Displays antitumor activity in a mouse model. Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation. Cell permeable.

Abbr

AG-879(NGFR)

Alias

alpha-Cyano-(3, 5-di-t-butyl-4-hydroxy)thiocinnamide

Appearance

Yellow powder

Product Overview

NGFR inhibitor

CAS_No

148741-30-4

Molecular Weight

316.5

Purity

>99% (TLC); NMR (Conforms)

Synonyms

alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide

Targets

NGFR

Molecular Formula

C18H24N2OS

Melting Point

223-224ºC

Solubility

May be dissolved in DMSO (25mg/ml) or Ethanol (20 mg/ml)

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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