Apicidin

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Cat No.

CEI-0495

Description

A potent, cell permeable inhibitor of histone deacetylase (IC₅₀ = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC₅₀ = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner.

Appearance

Gray solid

Product Overview

A HDAC inhibitor

CAS_No

183506-66-3

Molecular Weight

415.2

Purity

>98% by ⁵¹V-NMR

Storage

-20 centigrade

Targets

HDAC

Molecular Formula

C₃₄H₄₉N₅O₆

Chemical Name

cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid

Solubility

H₂O (>5 mg/ml)

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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