AS-605240

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Cat No.

CEI-0080

Description

AS-605240 is a high selective inhibitor of PI3K-gamma with IC50 of 8 nM.

CAS_No

648450-29-7

Molecular Weight

257.27

Purity

>99%

Storage

2 years at -20 centigrade

Targets

PI3K-gamma

Molecular Formula

C12H7N3O2S

Chemical Name

(Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione

Solubility

DSMO 0.4 mg/mL Water

In vitro

AS-605240 is an ATP-competitive PI3Kgamma inhibitor, with Ki values of 7.8 nM. AS-605240 is isoform-selective, for AS-605240 also inhibits PI3Kalpha, beta, and delta, with IC50 of 60, 270, and 300 nM, respectively.

In vivo

In a alphaCII-induced arthritis, AS-605240 (50 mg/kg) protects against alphaCII-IA symptom.In an obesity-induced diabetes model (ob/ob mice), AS-605240 (10 mg/kg) lowers blood glucose levels, significantly improves both insulin sensitivity and glucose tolerance without affecting body weight.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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