Aurora Kinase A active human, Recombinant

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Cat No.

NATE-0087

Description

Aurora A kinase also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle.

Abbr

ARK1, Recombinant (Human)

Alias

ARK1; AURA; BTAK; STK6

Source

baculovirus infected Sf9 cells

Species

Human

Applications

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Package

Minimum 50 ng protein/vial by Bradford

Product Overview

Human Aurora kinase A (GenBank Accession No. NM_003600), amino acids 2-403 with N-terminal HIS6-tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Form

aqueous solution

Activity

~17,000 units/mg protein

Molecular Weight

mol wt 50 kDa

Purity

> 90% (SDS-PAGE)

Unit Definition

One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Ser/Thr 1 peptide substarte per minute at pH 7.4 and 30°C.

Synonyms

Aurora Kinase A; Aurora A kinase; serine/threonine-protein kinase 6; AURKA; AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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