Bay 65-1942 free base

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Cat No.

CEI-1237

Product Overview

Bay 65-1942 free base is a selective inhibitor of IKKβ with IC50 value of 10 μM and Ki value of 2 nM. IKKβ (inhibitor of nuclear factor kappa-B kinase subunit beta) is a subunit of Iκ B kinase which regulates the NF-κ B activation and plays an important role in triggering immune responses. Bay 65-1942 is a potent IKKβ inhibitor. When tested with MYL-R cells, administration of Bay 65-1942 reduced cell viability and induced cell apoptosis by decreasing IKKβ expression. In human alveolar type II epithelium-like lung adenocarcinoma cell line A549, treatment of Bay 65-1942 inhibited IKKβ -dependent signal transduction and NF-κ B activation by inhibiting IKKβ. In acute ischemia-reperfusion C57BL/6 mice model, administration of Bay 65-1942 significantly reduced left ventricular infarct size and preserved cardiac function and finally prevented cardiac injury following IR by inhibiting IKK&beta

CAS_No

600734-02-9

Molecular Weight

395.45

Storage

Store at -20°C

Targets

IKKβ kinase

Molecular Formula

C22H25N3O4

Chemical Name

(7E)-7-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-5-[(3S)-piperidin-3-yl]-4,8-dihydro-1H-pyrido[2,3-d][1,3]oxazin-2-one

Solubility

DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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