BCl-2 Inhibitor GX15-070

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Cat No.

CEI-0406

Description

Cell-permeable. A small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–, and Mcl-1–mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.

Appearance

White solid

Product Overview

A Bcl-2 inhibitor

CAS_No

803712-67-6

Molecular Weight

175.14

Purity

>98% by NMR

Storage

-20 centigrade

Targets

Bcl-2

Molecular Formula

C 18 H 29 N 3 O

Chemical Name

(Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole

Solubility

DMSO (100 mM) or H₂O (100 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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