BIIB 021

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Cat No.

CEI-0536

Description

A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC50 values of 0.06, 0.31, and 0.14 µM, respectively.

Alias

CNF2024

Appearance

Light pink solid

Product Overview

A potent Hsp90 inhibitor

CAS_No

848695-25-0

Molecular Weight

645.83

Purity

>95% by HPLC

Storage

-20 centigrade

Synonyms

CNF2024

Targets

HSP90

Molecular Formula

C 14 H 15 ClN 6 O

Chemical Name

6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine

Solubility

DMSO (>10 mg/ml) or H₂O (>10 mg/ml)

Shipping Conditions

Gel pack

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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