BMS-265246

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Cat No.

CEI-0283

Description

BMS-265246

CAS_No

582315-72-8

Molecular Weight

345.34

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

CDK1/cyclin B, CDK2/cyclin E

Molecular Formula

C18H17F2N3O2

Chemical Name

(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2, 6-difluoro-4-methylphenyl)methanone

Solubility

DMSO 20 mg/mL, Water

In vitro

BMS265246 can potently inhibit CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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