BMS-345541

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Cat No.

CEI-1250

Description

BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC50 values of 4 μM and 0.3 μM, respectively.

Product Overview

BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC50 values of 4μM and 0.3μM, respectively. BMS-345541 is a highly selective inhibitor of IKK that inhibits NF-κB-dependent transcription of pro-inflammatory cytokines both in vitro and in vivo. This specificity is proved in the assay measuring the IKK-2-catalyzed phosphorylation of GST-IκB. In this assay, BMS-345541 fails to inhibit other serine/threonine and tyrosine kinases. This selectivity is also evident in cells, only the stimulus-induced phosphorylation of IκB was inhibited by BMS-345541 whereas other signal transduction cascades were unaffected. Since the IKK/ NFκB pathway is important for viability of leukemic cells and is a predictor of relapse in T-ALL, BMS-345541 is tested in some T-ALL cell lines. It is found that BMS-345541 can induce apoptosis and an accumulation of cells in the G2/M phase of the cell cycle. BMS-345541 can be used in combination with traditional therapies to overcome resistance to chemotherapeutic agents

CAS_No

547757-23-3

Molecular Weight

291.78

Purity

0.98

Storage

Store at -20°C

Synonyms

BMS-345541 hydrochloride; BMS 345541 hydrochloride

Targets

IKK

IC50

4 μM; 0.3 μM

Molecular Formula

C14H18ClN5

Chemical Name

N-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; hydrochloride

Solubility

Soluble in DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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