BMS-708163 (Avagacestat)

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Cat No.

CEI-0204

Description

BMS-708163 (Avagacestat) can inhibit Abeta42, Abeta40, and Abeta38 with IC50 of 0.79 nM, 0.78 nM and 0.66 nM.

CAS_No

1146699-66-2

Molecular Weight

520.88

Purity

>99%

Storage

2 years at -20 centigrade

Targets

Abeta42, Abeta40, Abeta38

Molecular Formula

C20H17ClF4N4O4S

Chemical Name

(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide

Solubility

DSMO 104 mg/mL Water

In vitro

BMS-708163, (R)-2-(4-chloro-N-(2-fluoro-4- (1,2,4-oxadiazol-3-yl)benzyl) phenylsulfonamido)-5,5,5-trifluor-opentanamide, is a novel, sulfonamide containing gamma -secretase inhibitor. BMS-708163 showed potent A beta 40 inhibition (1.4 nM) and >300-fold selectivity versus Notch (540 nM).

In vivo

Orally administered to Tg2576 mice (aged 5.5 months )for 8d. BMS-708163 significantly ameliorated cognitive deficits in Tg2576 mice on day 1, but not on day 8.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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