Bromodomain Inhibitor, (+)-JQ1

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Cat No.

CEI-0409

Description

Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.

Appearance

Crystalline solid

Product Overview

A potent and highly specific BET inhibitor

CAS_No

1268524-70-4

Molecular Weight

349.43

Purity

>99% by HPLC

Storage

-20 centigrade

Targets

BRD4

Molecular Formula

C23H25ClN4O2S

Chemical Name

t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Solubility

DMSO

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Project Description:

For research and industrial use only, not for personal medicinal use.

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