Calpain Inhibitor I, ALLN

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Cat No.

CEI-0414

Description

A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.

Alias

Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al

Appearance

White to off-white solid

Product Overview

A Calpain inhibitor

CAS_No

110044-82-1

Molecular Weight

692.71

Purity

>98%

Storage

Synonyms

Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al

Targets

calpain I, calpain II, cathepsin B, cathepsin L

Molecular Formula

C₂₀H₃₇N₃O₄

Solubility

H₂O (50 mg/ml)

Shipping Conditions

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1665	Cathepsin L from Human, Recombinant	EC 3.4.22.15		E. coli	Inquiry
NATE-0177	Native Human Cathepsin L	EC 3.4.22.15	60616-82-2	Human liver	Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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