Cambinol

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Cat No.

CEI-0648

Description

An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC50 = 56 µM) and SIRT2(IC50 = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53.

Alias

NSC-112546

Appearance

Off-white solid

Product Overview

A SIRT1 inhibitor

CAS_No

14513-15-6

Molecular Weight

403.52

Purity

>90% by HPLC

Storage

-20 centigrade

Synonyms

NSC-112546

Targets

SIRT1

Molecular Formula

C₂₁H₁₆N₂O₂S

Chemical Name

5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Solubility

DMSO

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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