Cercosporamide

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Cat No.

CEI-1076

Description

Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.

Abbr

Cercosporamide(MKNK2, JAK3, MKNK1)

Alias

GPRK7, MNK2

CAS_No

131436-22-1

Molecular Weight

331.28

Purity

>96 %

Stability

Stable under recommended storage conditions.

Storage

-20 centigrade

Synonyms

GPRK7, MNK2

Targets

Mnk2, JAK3, Mnk1

IC50

11nM, 31nM, 116 nM

Molecular Formula

C16H13NO7

Chemical Name

(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide

Solubility

Soluble to 10 mM in DMSO

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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