c-FMS inhibitor

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Cat No.

CEI-1275

Description

c-FMS inhibitor is a potent, orally active and small-molecule inhibitor of FMS kinase with IC50 value of 0.8 nM.

Product Overview

c-FMS inhibitor, 4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl) phenyl]-1H-pyrrole-2-carboxamide, is a novel FMS kinase inhibitors as anti-inflammatory agents with an IC50 value of 0.8 nM. c-FMS inhibitor resulted in identification of a highly potent series of 2,4-disubstituted arylamides. It served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice. c-FMS inhibitors has a potential to form reactive metabolites which are transformed into a series with equivalent potency by incorporation of carbon-based replacement groups. Structure-based model provides the framework to efficiently effect this transformation and restore potencies to previous levels. This optimization removed a risk factor for potential idiosyncratic drug reactions.

CAS_No

885704-21-2

Molecular Weight

406.52

Purity

0.98

Storage

Store at -20°C

Synonyms

1H-Pyrrole-2-carboxamide

Targets

FMS kinase

IC50

0.8 nM

Molecular Formula

C23H30N6O

Chemical Name

4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl]-1H-pyrrole-2-carboxamide

Solubility

Soluble in DMSO

Shipping Conditions

Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request

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Project Description:

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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