Chidamide

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Cat No.

CEI-0504

Description

Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.

Appearance

White solid

Product Overview

A potent histone deacetylase inhibitor

CAS_No

743420-02-2

Molecular Weight

382.45

Purity

>95% by HPLC

Storage

-20 centigrade

Targets

HDAC

Molecular Formula

C22H19FN4O2

Chemical Name

N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide

Solubility

DMSO (200 mM)

Shipping Conditions

Gel pack

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Project Description:

For research and industrial use only, not for personal medicinal use.

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