CHIR-124

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Cat No.

CEI-0285

Description

CHIR-124

CAS_No

405168-58-3

Molecular Weight

419.91

Purity

>99%

Storage

2 years at -20 centigrade

Targets

Chk1

Molecular Formula

C23H22ClN5O

Solubility

In vitro

CHIR-124 is a quinolone-based small molecule that is structurally unrelated to other known inhibitors of Chk1. CHIR-124 interacts synergistically with topoisomerase poisons (e.g., Camptothecin or SN-38) in causing growth inhibition in a variety of cancer cell lines, including breast carcinoma (MDA-MB-231 and MDA-MB-435) and colon carcinoma (SW-620 and Colo205), all of which contains the mutant p53 gene.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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