CHIR-99021(CT99021)

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Cat No.

CEI-0123

Description

CT99021(CHIR-99021) can inhibit GSK3alpha and GSK3beta with IC50 of 10 nM and 6.7 nM.

CAS_No

252917-06-9

Molecular Weight

465.34

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

GSK3alpha, GSK3beta

Molecular Formula

C22H18Cl2N8

Chemical Name

6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile hydrochloride

Solubility

DMSO 100 mg/mL Water 100 mg/mL Ethanol 20 mg/mL

In vitro

As a potent inhibitor, CT99021(CHIR-99021) can inhibit GSK3alpha and GSK3beta with IC50 of 10 nM and 6.7 nM. Inhibition of GSK3 with CT99021 (3 microM) resulted in a significant increase in the percentage and quality of blastocysts. CT99021 can reduced the phosphorylation of beta-catenin on Ser45 in two-cell embryos.

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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