Cucurbitacin I

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Cat No.

CEI-1077

Description

Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Abbr

Cucurbitacin I(STAT3, JAK2)

Alias

APRF, HIES

CAS_No

2222-07-3

Molecular Weight

514.65

Purity

>98 %

Stability

Stable under recommended storage conditions.

Storage

-20 centigrade

Synonyms

APRF, HIES

Targets

STAT3, JAK2

Molecular Formula

C30H42O7

Chemical Name

(9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

Solubility

Soluble to 10 mM in DMSO and to 20 mM in ethanol

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Project Description:

For research and industrial use only, not for personal medicinal use.

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