Cytarabine

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Cat No.

CEI-0319

Description

Cytarabine

CAS_No

147-94-4

Molecular Weight

243.22

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

DNA synthesis

Molecular Formula

C9H13N3O5

Solubility

DMSO 1 mg/mL, Water 48 mg/mL, Ethanol

In vitro

Cytarabine (AraC) is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM.

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