D-Ala-D-Ala dipeptidase

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Cat No.

EXWM-4036

Description

A Zn2+-dependent enzyme. The enzyme protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide (see diagram). This enzyme reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)-lactate (for which vancomycin has much less affinity)to be added to the cell wall instead. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. Belongs in peptidase family M15.

Form

Liquid or lyophilized powder

Enzyme Commission Number

EC 3.4.13.22

Storage

Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.

Synonyms

D-alanyl-D-alanine dipeptidase; vanX D-Ala-D-Ala dipeptidase; VanX

Reaction

D-Ala-D-Ala + H2O= 2 D-Ala

Notes

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

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Project Description:

For research and industrial use only, not for personal medicinal use.

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