Dithiothreitol (DTT)

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Cat No.

DTGZ-0001

Description

Dithiothreitol is a high-purity thiol reducing reagent supplied as a crystalline powder for cleaving disulfide bonds and maintaining sulfhydryl groups in the reduced state.

Abbr

DTT

Alias

DL-Dithiothreitol; (±)-Dithiothreitol; 1,4-Dithiothreitol; threo-1,4-Dimercapto-2,3-butanediol

Applications

Reduction of protein disulfide bonds; protection of sulfhydryl groups; protein sample preparation; electrophoresis and general biochemical workflows.

Appearance

White crystalline powder.

Package

1 g
5 g
25 g
100 g

Product Overview

This small-molecule reagent contains two thiol groups and is commonly used to establish reducing conditions during protein handling and biochemical analysis.

Form

Powder

CAS_No

3483-12-3

Molecular Weight

154.25 g/mol

Purity

99%

Structure

HSCH₂CH(OH)CH(OH)CH₂SH

Stability

Sensitive to oxidation by air, particularly after dissolution.

Storage

Store at 2-8°C in a tightly sealed container. Protect from moisture and air.

Warnings

Avoid prolonged exposure to air and moisture. Prepare aqueous solutions freshly when reducing performance is critical.

Function

Thiol reducing agent for disulfide-bond cleavage and sulfhydryl-group protection.

Synonyms

Dithiothreitol; DL-Dithiothreitol; Cleland's reagent; DTT; 1,4-Dithiothreitol

Molecular Formula

C₄H₁₀O₂S₂

Chemical Name

DL-1,4-Dimercapto-2,3-butanediol

MDL Number

MFCD00004877

Melting Point

41-45°C

Solubility

Soluble in water, methanol, and dichloromethane.

Quality

Biochemical reagent; 99%

Grade

Notes

The reduced reagent is converted to a stable cyclic disulfide during reduction reactions.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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