DL-α-Methylleucine

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Cat No.

CEGZ-6918

Description

DL-α-Methylleucine is an α-methylated analogue of the proteinogenic amino acid leucine, supplied as the racemic DL mixture. The additional methyl group at the α-carbon creates a quaternary center that markedly restricts backbone conformational freedom.

Applications

Used as a building block and research intermediate for the preparation of conformationally constrained, protease-resistant peptide analogues and in structure-activity relationship studies.

Product Overview

α-Methyl amino acids are important tools in peptide and medicinal chemistry: their incorporation stabilizes helical and turn conformations and confers strong resistance to proteolytic degradation, properties that are exploited in the design of peptide-based drug candidates.

CAS_No

144-24-1

Molecular Weight

145.20

Storage

Store in a tightly closed container in a cool, dry place.

Synonyms

DL-2-amino-2,4-dimethylpentanoic acid; alpha-methyl-DL-leucine

Molecular Formula

C7H15NO2

Notes

For research and development use only.

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Project Description:

For research and industrial use only. Not intended for personal medicinal use. Certain food-grade products are suitable for formulation development in food and related applications.

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