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Dutasteride

Cat No.
CEI-0210
Description
Dutasteride
Alias
GI198745, GG-745
CAS No.
164656-23-9
Molecular Weight
528.53
Purity
>99%
Storage
2 years at 20centigrade Powder
Synonyms
GI198745, GG-745
Targets
5 alpha-reductase
Molecular Formula
C27H30F6N2O2
Chemical Name
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
Solubility
DMSO 62 mg/mL, Water
In vitro
Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used for the treatment of benign prostatic hyperplasia (BPH) and is prescibed off-label for the treatment of male pattern baldness (MPB). Dutasteride inhibits both isoforms of 5-alpha reductase (5aR1 and 5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 ?M.

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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