Eltrombopag (SB-497115-GR)

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Cat No.

CEI-0364

Description

Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 uM for the inhibition of hERG K+ channel tail current. In preclinical studies, the compound was shown to interact selectively with the thrombopoeitin receptor, leading to activation of the JAK-STAT signaling pathway and increased proliferation and differentiation of megakaryocytes. Animal studies confirmed that administration could increase platelet counts.

Alias

SB-497115-GR, Revolade, Promacta

CAS_No

496775-61-2

Molecular Weight

442.47

Purity

>99%

Storage

2 years at -20centigrade Powder

Synonyms

SB-497115-GR, Revolade, Promacta

Targets

thrombopoietin receptor

Molecular Formula

C25H22N4O4

Chemical Name

3-[(5E)-5-[[2-(3, 4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6- oxocyclohexa-1,3-dien-1-yl]benzoic acid

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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